NNC 55-0396

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性 T 型钙通道拮抗剂，可阻断人胚肾 293 细胞中的重组 α(1)G T 型通道，IC50 为 7 uM。

A potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM; has no detectable effect on high-voltage-activated channels in INS-1 cells; inhibits MCF-7 (ERalpha+) cellular proliferation, inhibits tumor-induced angiogenesis in vitro and in vivo by suppressing HIF-1α stability; significantly suppresses glioblastoma tumor growth in a xenograft model.

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Animal Model:GABAA receptor α1 subunit null mouse model Dosage:20 mg/kg Administration:Intraperitoneal injection; 20 mg/kg, once Result:Suppressed tremor in GABAA subunit α1-null mice.

NNC 55-0396 dihydrochloride

GPCR/G Protein

Calcium Channel

Calcium Channel

Cardiovascular Disease

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357400-13-6

564.5619

C30H40Cl2FN3O2

>98% (HPLC)

DMSO

CC(C)C1C2=C(CCC1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)C5CC5)C=C(C=C2)F.Cl.Cl

Cyclopropanecarboxylic acid, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, hydrochloride (1:2)

(-20℃)

With Ice Pack

≥ 2 years